Turn off the in-game frame limiter, but use an external tool (like RivaTuner) to cap the game at 60 FPS. GTA San Andreas physics can break if the frame rate exceeds 100 FPS.
SSD is highly recommended to prevent texture pop-in Key Optimization Tips
Here is the definitive guide to the system requirements for SA DirectX 3.0 (Fixed). Why the "Fixed" Version?
The "Fixed" version usually includes an improved enbseries.ini . Ensure VideoMemorySizeMb is set correctly to match your GPU's dedicated memory.
To run the mod at 30-45 FPS on Low/Medium settings at 1080p. Windows 7, 8.1, or 10 (64-bit recommended) Processor: Intel Core i5-2500K / AMD FX-6300 Memory (RAM): 8 GB RAM